<i>Moringa stenopetala</i> leaf extract improves the efficacy of doxorubicin in the breast cancer therapy by suppressing the expression of MDR-1, Raf-1, and Top-II

Abstract

qPCR. Thirty-two compounds were identified in the ethanolic extract using HPLC ESI-MS/MS and classified into: hydroxycinnamic acid derivatives, flavonoids, fatty acids, and other miscellaneous compounds. Molecular docking predicted that the main component in the ethanolic extract (apigenin-7-O-rutinoside) has multiple inhibitory effects on MDR-1, Raf-1 and Top-II proteins.