Wolbachia and Lymphatic Filarial Nematodes and Their Implications in the Pathogenesis of the Disease

Abstract

Lymphatic filariasis (LF) is an infection of three closely related filarial worms such as <i>Wuchereria bancrofti</i>, <i>Brugia malayi</i>, and <i>Brugia timori</i>. These worms can cause a devastating disease that involves acute and chronic lymphoedema of the extremities, which can cause elephantiasis in both sexes and hydroceles in males. These important public health nematodes were found to have a mutualistic relationship with intracellular bacteria of the genus <i>Wolbachia</i>, which is essential for the development and survival of the nematode. The host's inflammatory response to parasites and possibly also to the <i>Wolbachia</i> endosymbiont is the cause of lymphatic damage and disease pathogenesis. This review tried to describe and highlight the mutualistic associations between <i>Wolbachia</i> and lymphatic filarial nematodes and the role of bacteria in the pathogenesis of lymphatic filariasis. Articles for this review were searched from PubMed, Google Scholar, and other databases. Article searching was not restricted by publication year; however, only English version full-text articles were included.