Vitamin D Ameliorative Effect on some Immunological Aspects of Type II Diabetes Mellitus in Rat Model

Abstract

Background: Type II Diabetes and its complications is a worldwide epidemic and a significant cause of illness and death. Since the precise link between the level of vitamin D and immune status in diabetes is still unknown, this research may help create new potential therapies to prevent diabetic complications. Aim: To find out the impact of vitamin dietary supplementation on Type II diabetes immunological aspects Materials and methods: The current experimental randomized prospective study was carried out in the Medical Physiology Department, Medical division, National Research Center on thirty albino male rats. Three groups—negative Control, positive diabetic control, and diabetic with intramuscular injections of 20,000 IU/kg Vitamin D3 were included in the study. Insulin, fasting blood glucose (FBG), homeostasis model assessment for insulin resistance (HOMA-IR) and inflammatory markers were measured. Results: HOMA-IR, nuclear factor kappa B (NF-KB), tumor necrosis factor-α (TNF-α), Interleukin 1B (IL-1B), C reactive protein (CRP) and immunoglobulin A (IgA), were considerably lower in treated group than positive control group. Conclusion: After treatment, glucose was much lower in the group treated with vitamin D. As a result, vitamin D administration may enhance glycemic management in those with type 2 diabetes mellitus.