Value of LDH in Lymphoproliferative disorders

Abstract

Both the lymphatic tissues (as in lymphoma) & the bone marrow (as in leukaemia & myeloma) may be the site of lymphoproliferative diseases. Depending on the type & other personal circumstances, the course of the disease & its treatment can differ significantly. Subjects & methods the research carried out on60 patients, divided into3 groups, group I: 20 ALL patients, group II: 20 CLL patients and 20 NHL patients. Each patient was subjected to complete history taking, clinical examination, laboratory investigations in the form of routine investigations; CBC, LDH. Bone marrow aspiration, Immunophenotyping on bone marrow samples defined by Flowcytometer for routine panel of B cell lymphoid disorder. Results: significant statistically (p-value = 0.008) Age & LDH have a negative connection (r = - 0.59). Significant statistically high (p-value < 0.001) Correlation among lymph percentage & LDH is negative (r = - 0.74). Positive association (r = 0.58), statistically significant (p-value = 0.008) among lymph & LDH (abs). Positive correlation (r = 0.67), statistically significant (p-value = 0.002) among peripheral blast & LDH. Following therapy, there had been a positive correlation (r = 0.51) among peripheral blast & LDH that had been statistically significant (p-value = 0.024). Conclusion: LDH level act as valuable markers for managing lymphoprolieferative disorder. Its clinical applications can guide treatment strategies for this disease.