Use of Lyophilized Growth Factors Foam in Chronic Ulcers

Abstract

Background: Treatment of chronic ulcers involves addressingthe underlying cause and interventions to improvethe process of healing such as autologous platelet-rich plasma.Platelet-rich plasma has been extensively studied for its potentialin promoting healing of chronic ulcers as it contains ahigh concentration of growth factors such as platelet derivedgrowth factor, epithelial growth factor and fibroblast growthfactor. Advanced growth factor delivery systems have been developedto prolong the bio-activity of growth factors.LGF have been developed by a patented method to overcomethe discrepancies of conventional platelet rich plasma.Objective: In this study, we present LGFoam as a topicalagent containing Lyophilized growth factors, for use in chroniclower limb ulcers for the purpose of improving healing.Methodology: Comparison of ulcer size between LGFoamtopically applied to non-healing lower limb ulcers of variousetiologies, as opposed to conventional dressing with a 30-dayfollow-up period.Conclusion: Several advanced growth factors deliverysystems have been developed for topical use. However, conflictingevidence exists for their efficacy, warranting furtherresearch.In our study, there was a statistically significant decreasein ulcer size for the LGFoam group, encouraging future studiesinto its use in promoting wound healing in general, especiallychronic non-healing ulcers as a problematic entity.