article · Annals of Internal Medicine Clinical Cases
Hodgkin lymphoma (HL) is characterized by Reed–Sternberg cells. Eosinophilia is an expected finding in patients with HL. However, there are few reports of hypereosinophilia in HL. We report a 45-year-old woman with fever, lymphadenopathy, and abdominal distention. Her complete blood count at presentation showed a total leukocyte count of 60 800 cells/mm3 with an eosinophil count of 46 000 cells/mm3. Lymph node biopsy revealed lymphocyte-rich HL, with eosinophil count dropping to 90 cells/mm3 after chemotherapy. Hypereosinophilia is unusual and needs to be extensively investigated. In HL, hypereosinophilia is thought to occur from cytokine secretion by Reed–Steinberg cells.
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DOI: 10.7326/aimcc.2023.0012
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