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article · Frontiers in Endocrinology

Type 1 diabetes impairs the activity of rat testicular somatic and germ cells through NRF2/NLRP3 pathway-mediated oxidative stress

202415 citationsOpen accessUniversity of Monastir

Abstract

The combined data allowed us to confirm that T1D has detrimental effects on rat testicular activity. Moreover, a better comprehension of the molecular mechanisms underlying the association between metabolic disorders and male fertility could help to identify novel targets to prevent and treat fertility disorders related to T1D.

Research topics

  • Heme Oxygenase-1 and Carbon Monoxide
  • Sperm and Testicular Function
  • Paraoxonase enzyme and polymorphisms

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DOI: 10.3389/fendo.2024.1399256

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