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article · Frontiers in Oncology

Tumor lysis syndrome in children with hematological malignancies: a nephrology perspective in resource-limited settings

2026Open accessAlexandria University

Abstract

In pediatric TLS, AKI severity is the main determinant of clinical outcome. Dynamic phosphate kinetics (Delta phosphorus), rather than static biochemical thresholds, represent a robust early biomarker for identifying children at risk of severe AKI and may improve risk stratification, particularly in resource-limited settings.

Research topics

  • Methemoglobinemia and Tumor Lysis Syndrome
  • Fluoride Effects and Removal
  • Acute Lymphoblastic Leukemia research

Sustainable Development Goals

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DOI: 10.3389/fonc.2026.1778776

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