article · Drug Design Development and Therapy

Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis

Abdullah R. Alzahrani
Doaa I. Mohamed
Hebatallah H. Abo Nahas
Mariusz Jaremko
Abdulmalik Saleh Alfawaz Altamimi
Ibrahim Abdel Aziz Ibrahim
Ghazi A. Bamagous
Dalia Alaa El-Din Aly El-Waseef
Nasser A. Elhawary
Alaa Hisham Falemban
Soha M. Y. Mohamed
Yasmine Gamal Sabry
Ibrahim H Youssef
Essa M. Saied

20249 citationsOpen accessAin Shams University

Abstract

Taken together, our study showed for the first time the interplay between epigenetic lncRNAs CBR3-AS1 and miRNA-29 in lung fibrosis and demonstrated that FIZZ1 could be a downregulatory gene for lncRNA CBR3-AS1 and miRNA-29. Our key findings demonstrate that TMZ significantly reduces the expression of fibrotic, oxidative stress, immunomodulatory, and inflammatory markers, along with epigenetic regulators associated with lung fibrosis. This validates its potential as an effective antifibrotic agent by targeting the CBR3-AS1/miRNA-29/FIZZ1 axis.

Research topics

Cancer-related molecular mechanisms research
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Transplantation: Methods and Outcomes

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DOI: 10.2147/dddt.s463626

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