article · Cureus

Trial-Adjusted Versus Generic Simulated Comparator Trial (SCT) Settings for Selection Bias Appraisal Using the I2 Test

20242 citationsOpen accessUniversity of the Witwatersrand

Abstract

I<sup>2</sup> testing with trial-adjusted SCT settings increased the odds of identifying selection bias in clinical trials and did not significantly alter the odds in smaller trials with fewer than 200 patients per intervention group.

Research topics

Statistical Methods in Clinical Trials
Optimal Experimental Design Methods
Meta-analysis and systematic reviews

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DOI: 10.7759/cureus.71668

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