review · Advances in Pharmacological and Pharmaceutical Sciences
Calendula arvensis L. is an ornamental and medicinal plant widely distributed across Mediterranean countries and southern Europe, long utilised in traditional medicine for diverse health disorders. Scientific data shows that extracts and essential oils from the plant are rich in bioactive compounds, including fatty acids, sterols, phenolics, flavonoids, saponins, tannins, alkaloids, and terpenoids. These chemical constituents underpin an extensive range of documented pharmacological activities, such as anti-inflammatory, antimicrobial, antitrypanosomial, antitumoral, antimutagenic, antioxidant, insecticidal, and immunomodulatory actions, as well as wound treatment capabilities and hemolytic properties. While these findings validate the plant's broad therapeutic value in folk remedies, significant gaps remain. Systematic toxicological examinations and pharmacokinetic validation must be conducted to establish safety and assess potential adverse effects before any clinical trials can be pursued.
Traditional medicinal plants offer valuable starting points for modern medical discoveries. Cataloguing the active compounds and validated pharmacological properties of Calendula arvensis bridges ancient medical knowledge with contemporary evidence. This information helps medical and pharmaceutical researchers evaluate which natural constituents could serve as bases for therapies targeting infections, inflammation, and other complex health conditions.
The research points to potential applications in wound care, anti-inflammatory therapies, and antimicrobial product development, relevant to pharmaceutical and botanical product developers. However, the work remains at an early discovery stage. Significant safety hurdles remain, as the compounds require formal pharmacokinetic validation and toxicological evaluation to rule out adverse effects prior to any clinical testing or commercial formulation.
AI-generated from the published abstract. Always read the original work before citing.
Calendula arvensis L. (Asteraceae) is a famous ornamental and medicinal plant widely distributed in Mediterranean countries and the southern region of Europe. This reputed species is widely used in traditional medicine in the treatment of many disorders and has various bioactivities, especially anti-inflammatory, antiviral, antimutagenic, antimicrobial, insecticidal, antioxidant, and immunomodulatory activities. The present review was conducted to provide a critical review of the comprehensive and current knowledge regarding C. arvensis species, in particular, its taxonomy and geographical distribution, botanical description, medicinal uses, phytochemical compounds, pharmacological properties, and toxicity investigations. The data collected on C. arvensis were obtained using different scientific research databases such as PubMed, SciFinder, SpringerLink, Web of Science, Science Direct, Google Scholar, Wiley Online, and Scopus. Phytochemical screening of different C. arvensis extracts and essential oils showed their richness in bioactive compounds, particularly in fatty acids, sterols, phenolics, flavonoids, saponins, tannins, alkaloids, and terpenoid compounds. The findings of this review showed that the pharmacological activities of C. arvensis confirm its importance and diversity as a traditional remedy for many diseases. This plant presents a wide range of bioactivities, namely, anti-inflammatory, antimicrobial, antitrypanosomial, antitumoral, antimutagenic, and immunomodulatory activities, as well as hemolytic properties and wound treatment. Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1155/2023/2482544
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
