TOXICITY EFFECT OF LEAF EXTRACT OF Cassia angustifolia ON BRAIN AND HEMATOLOGICAL PARAMETERS OF WISTAR RATS

Abstract

Background/aim: plants has been the secret lock of many ailment. But understanding the sustained effect of this plant is important to avoid causing health complication. Objective: The effects of subacute Cassia angustifolia on the brain and blood, parameters of wistar rats were investigated in this study. Methods: Rats of both sexes were employed in the experiment. In contrast to groups 2, 3, and 4, which received 50, 100, and 200 mg/kg of Cassia angustifolia, group 1 received distilled water (10 ml/kg). Animals were housed in standard cages for 28 days and given oral access to the extract before being weighed and scarified. The haematoxylin and eosin (H&E) staining technique was used for histological studies on the effects of the plant. The brain and heart were also meticulously taken and histologically examined. RBC, HGB, and MCV levels considerably dropped (P <0.05), whereas neutrophils, basophils, eosinophils, and platelets remained unaltered. Results: RBC, HGB, and MCV levels considerably dropped (P<0.05), whereas neutrophils, basophils, eosinophils, and platelets remained unaltered. The brains of rats at 100 mg/kg were found to be slightly larger than those of control rats given 50 and 200 mg/kg. Histological examination of the brain revealed normal features at all doses. Conclusion: Ethanol leaf extract of Cassia angustifolia showed no harmful effect to the brain tissue, thus allaying local concerns about it impact on the brain.