article · Pharmaceuticals

Thymol Protects against 5-Fluorouracil-Induced Hepatotoxicity via the Regulation of the Akt/GSK-3β Pathway in In Vivo and In Silico Experimental Models

Yasmen F. Mahran
Amira M. Badr
Nouf T. Al‐Damry
Nervana Bayoumy
Elshaymaa I. Elmongy
Layla A. Al‐Kharashi
Hanaa N. Alajami
Sahar Soliman

202411 citationsOpen accessAin Shams University

Abstract

Our research is the first to shed light on thymol's potential protective effect against 5-FU- induced hepatotoxicity by inhibiting oxidative and apoptotic pathways and modulating the Akt/ GSK-3β as well as p44/42 MAPK (ERK1/2) signaling pathways.

Research topics

Drug-Induced Hepatotoxicity and Protection
Chemotherapy-induced organ toxicity mitigation
Pharmacogenetics and Drug Metabolism

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.3390/ph17081094

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