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article · Cureus

Thrombolysis as Part of Acute ST-Segment Elevation Myocardial Infarction (STEMI) Care: Experience From the STEMI Network in Tanzania

In plain language

Ischaemic heart disease represents a growing health challenge in low- and middle-income countries, where prompt diagnosis and intervention are critical for patient survival. A cross-sectional survey evaluated the resources, infrastructure, and referral systems available for managing acute ST-segment elevation myocardial infarction across healthcare centres in mainland Tanzania and Zanzibar. Evaluating responses from 66 medical practitioners across public and private hospitals, the investigation revealed significant gaps in emergency cardiac care. Thrombolytic medications were present in only a quarter of public facilities and less than half of private centres. Crucial primary angioplasty infrastructure was heavily skewed geographically, with catheterisation laboratories situated solely within the coastal and central regions. Furthermore, under a third of clinicians could transfer patients for advanced care within the recommended 90-minute window, demonstrating that institutional capacity remains restricted and unequally spread.

Key takeaways

  • Thrombolytic medications are available in only 25 percent of public facilities and 47 percent of private facilities surveyed in Tanzania.
  • Specialised catheterisation laboratories are concentrated in the coastal and central regions, leaving other zones without primary angioplasty access.
  • Only 31 percent of private facility clinicians and 23 percent of public facility clinicians can refer patients for advanced care within the recommended 90 minutes.
  • Overall capacity to treat ST-elevation myocardial infarction is low and unevenly distributed between public and private sectors.

Why it matters

Prompt treatment is essential to survive a severe heart attack. This assessment demonstrates that essential medicines and catheterisation facilities are scarce and unevenly distributed across Tanzania. Recognising these infrastructure shortfalls helps health administrators and policymakers design better referral networks, allocate emergency medicines more effectively, and improve timely emergency cardiac care for patients in resource-limited settings.

Commercialisation angle

The findings highlight an applied healthcare system assessment rather than a commercial product, though the evidence identifies clear operational requirements for pharmaceutical supply chains and diagnostic distribution. Potential users of this information include healthcare network planners, medical logistics providers, and policymakers seeking to expand access to cardiovascular medicines and clinical referral tools. The abstract does not indicate an immediate commercial application pathway.

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Abstract

Background and objective The burden of ischaemic heart disease (IHD) in low- and middle-income countries (LMIC) is increasing worldwide. A significant proportion of hospitalizations and deaths have been attributed to this condition. Promoting good clinical outcomes in patients with IHD requires timely diagnosis and management using percutaneous coronary intervention (PCI) and recommended pharmacotherapy. Fibrinolytics, combined with antiplatelet and anticoagulant agents, are recommended as initial therapy in resource-limited settings. The regional systems, which aim to provide access to timely percutaneous intervention for patients with ST-elevation myocardial infarction (STEMI), are still in their infancy stages in Tanzania. However, these systems have shown promising results in coordinated patient management. This survey was conducted through a network to gain an understanding of the general context of IHD management. This study aimed to assess the current service availability, infrastructure in place, and the duration of time taken between various referral centers in different zones. Methodology An online cross-sectional survey was conducted between May and June 2023, involving medical practitioners from facilities in mainland Tanzania and Zanzibar. Physicians from various regional centers were invited to complete an anonymous online survey about the available STEMI services and their familiarity with the pathway. Information on geography, available expertise, equipment, and medicines at these facilities was collected and analyzed using R software, version 4.3.1. Proportion and frequencies were the primary measures for assessing the capacity and distribution of these facilities. A chi-square test was used to compare these parameters between public and private facilities, with the significance level set at p<0.05. All ethical standards were adhered to, and approval was obtained from the ethics committee. Results Among the 66 clinicians from mainland Tanzania and Zanzibar, 36 (54.5%) worked in public facilities, while 30 (45.5%) worked in private facilities. Clinician responses from the coastal regions were obtained from 18 (50%) public facilities and 10 (33%) private facilities, indicating an uneven distribution of thrombolysis and primary angioplasty services in this region. Only a quarter (n=9, 25%) of clinicians from the public and less than half (n=14, 47%) of the clinicians from private facilities reported the availability of thrombolytic medications in their facilities. Moreover, 11 (31%) and seven (23%) clinicians from private and public facilities, respectively, could refer patients for advanced care within the recommended 90 minutes after initial medical contact. Primary angioplasty services were concentrated in the coastal and central regions of the country, with four catheterization laboratories in the Dar es Salaam region (coastal) and one in the Dodoma Region (central). Conclusions Facilities offering medical services to patients with myocardial infarction (MI) are unevenly distributed in Tanzania, with a concentration mainly in the coastal region. These facilities have established protocols to care for patients with STEMI. The capacity of facilities is generally low and varies between public and private facilities. Further research is necessary to inform policies, and deliberate strategies and efforts are required to address the prevailing situation.

Research topics

  • Acute Myocardial Infarction Research
  • Acute Ischemic Stroke Management
  • Heart Failure Treatment and Management

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DOI: 10.7759/cureus.86337

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