article · Integrative Cancer Therapies
Camel milk and exosomes derived from it demonstrate potential as anticancer treatments against MCF7 cancer cells. When evaluated, the milk-derived exosomes exhibited a stronger anticancer effect than whole camel milk, although they triggered a lower immune response. The method of delivery also influenced outcomes, with local injection of the exosomes showing greater improvement compared to oral administration. The observed anticancer activity appears to operate through several cellular mechanisms within the tumour microenvironment. These processes include the induction of programmed cell death, or apoptosis, alongside the suppression of oxidative stress, inflammation, blood vessel formation, and cancer spread. Consequently, both camel milk and its isolated exosomes present viable candidates for further evaluation as therapeutic agents in cancer treatment strategies.
Finding natural substances that combat tumour growth provides valuable leads for oncology therapeutics. Demonstrating that camel milk and specifically its exosomes can suppress tumour processes such as metastasis, blood vessel formation, and inflammation highlights potential alternative avenues for developing targeted cancer interventions with distinct delivery requirements.
This early-stage research points towards potential pharmaceutical development of camel milk exosomes as oncology therapeutics. Biotechnology or drug formulation developers exploring bio-derived vesicles for local injection could utilise these findings. However, because the work remains at the laboratory stage evaluating MCF7 cells in vitro and in vivo, substantial preclinical validation and clinical testing will be required before any real-world application.
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Overall, administration of camel milk-derived exosomes showed better anticancer effect, but less immune response, than treatment by camel milk. Moreover, local injection of exosomes led to better improvement than oral administration. These findings suggest that camel milk and its exosomes have anticancer effect possibly through induction of apoptosis and inhibition of oxidative stress, inflammation, angiogenesis and metastasis in the tumor microenvironment. Thus, camel milk and its exosomes could be used as an anticancer agent for cancer treatment.
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DOI: 10.1177/1534735418786000
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