THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE

Abstract

Trichinosis is a common infection that spreads primarily through food. None of the therapies,including albendazole (ALZ), have significant effectiveness against Trichinella spiralis larvaeencapsulated in muscle, so there is a need to find new, effective trichinosis medications. Acacianilotica (A. nilotica) is linked to many biological activities as anti-inflammatory, anti-microbialand anti-carcinogenic activities. This study determined the efficacy of A. nilotica alone or incombination with ALZ for treating intestinal and muscular trichinosis.In this study, fifty mice were divided into five groups, non-infected control group, T. spiralisinfected control group, A. nilotica-treated group, ALZ treated group and finally Acacia-ALZtreated group. Adult count, larval load, intestinal and muscular histology, COX2 expression, andmeasurement of CD4+ & CD8+ lymphocytes percentages were investigated.The results showed that mice received the combined therapy achieved the greatest outcomes interms of the criteria employed. ALZ was better than Acacia for intestinal trichinosis, althoughAcacia was better for muscular trichinosis.