The variability in pattern, presentation, and outcomes in the management of congenital corrected transposition of the great artery(ccTGA) : A Systematic Review and Meta-analysis.

Abstract

Background: Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart disease with varying regional reports in management approach. The meta-analysis is aimed to document various regional differences in the pattern, presentation, and outcomes in the management of congenitally corrected transposition of the great artery(ccTGA). Methodology: statistics. Results: Fifty-one full articles were screened from the initial four hundred and eighty citations. A total of 37 studies were further excluded from the 51 studies after further screening for incomplete data, case reports, non-English language reportage, and studies from autopsy findings. The resultant 14 studies were presented in PRISMA. The statistical significance was observed as evidenced by the significance heterogeneity identified in the selected studies. Conclusion: The review had shown that children with ccTGA presented with varying features with some chromosomal correlates. Management options are directed towards a high index of suspicion, early intervention, and prompt surgical care to avert the numerous complications that follow the disease.