The Role of Anti-Nuclear Antibodies in Recurrent Abortion of Immunological Origin

Abstract

Background: Recurrent pregnancy loss (RPL) is the happening of two or more miscarriage events before the 20th week of pregnancy. This research aimed to assess the role of ANA in recurrent pregnancy loss of immunologic origin in Egyptian pregnant females.Patients and methods: This was a case-control research performed on 70 women in their first trimester of pregnancy at Zagazig University Hospitals. Patients were subdivided into 2 groups.Results: There was a significant association between RPL and both positivity of ANA (OR=4.337, p=.076) and parity (OR= 1.62, p=.054) at significance level of 0.1 which is acceptable as non-standard p-value, that means a female with positive ANA test has 4.3 times chances to have RPL compared to a female with negative ANA test, also females with each one increase in number of previous successful given births (parity) has a correspondent 1.621 times increase of probability to have recurrent pregnancy lossConclusion: (ANA) has important role in prognosis recurrent pregnancy loss. Therefore, we can benefit from Examination ANA to diagnose or predict a threatened miscarriage.