article · Asian Pacific Journal of Cancer Prevention

The Overexpression of NUSAP1 and GTSE1 Could Predict An Unfavourable Prognosis and Shorter Disease Free Survival in ccRenal Cell Carcinoma

Maram El‐Hussieny
Dalia M. Thabet
Heba M. Tawfik
Mariana F. Gayyed
Nisreen Toni

20244 citationsOpen accessMinia University

Abstract

We demonstrated that NUSAP1 and GTSE1 overexpression was closely related to the poor prognostic clinicopathological features of ccRCC and predicted an unfavorable prognosis. Therefore, NUSAP1 and GTSE1 might act together as potential futuristic prognostic indicators and therapeutic targets for ccRCC patients. However, further analysis in molecular studies on larger scale are mandatory to highlight the interactive crosstalk regulatory mechanisms between both markers and their combined effect on ccRCC.

Research topics

Cancer-related gene regulation
Epigenetics and DNA Methylation
Ubiquitin and proteasome pathways

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DOI: 10.31557/apjcp.2024.25.7.2551

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