The influence of lymphatic vessels on nanoparticle distribution and heat transfer within tissue

Abstract

Abstract This study analytically investigates the dynamics of nanoparticle transport within a three‐dimensional porous cylinder simulating a lymphatic vessel, without external heat sources. The governing equations and boundary conditions are transformed to yield a system of ordinary differential equations, which are solved numerically using MATLAB built‐in function, bvp4c . Key parameters are visually examined and physically interpreted in relation to temperature, velocity, concentration, and Nusselt number profiles. The study reveals that the distribution of temperature and Nusselt number are maximized by increasing the heat transfer coefficient, whereas NP concentration is increased by decreasing it. Furthermore, the Brownian motion parameter enhances both heat transmission and NP concentration. It is also observed that simpler extravasation into lymphatics decreases tissue nanoparticle levels and heat conduction. Ultimately, optimal intra‐lymphatic nanoparticle distribution pathways are achieved by specifically varying heat transfer and interstitial mass flux patterns. By simulating biological barriers and lymphatic drainage, this model enhances our understanding of the underlying transport mechanisms controlling nanoparticle mobilization.