The influence of Hydroxyzine Premedication on Preoperative Hemodynamics in Pediatric Patients

Abstract

BACKGROUND: Hydroxyzine is an antihistamine that belongs to the first generation of H1 Antihistamines and used in medicine for a variety of purposes. It was introduced into the field of anesthesia for a variety of reasons, including its sedative, antiemetic and anti-allergic properties. Therefore, it's critical to understand how hydroxyzine premedication affects hemodynamic changes in individuals, particularly in younger ones undergoing surgery OBJECTIVES: The objective of this study was to identify the impact of administering hydroxyzine orally before surgery on hemodynamics prior to induction of anesthesia in pediatric patients undergoing adenotonsillectomy. MATERIALS AND METHODS: In a randomized, double-blinded, prospective trial, a total of 60 children, aged 3-10 years old and of both genders were divided into two equal groups. Group A received oral hydroxyzine at a dosage of 1mg/kg, mixed with 10 ml of apple juice, one hour before to the initiation of anesthesia. Group B was administered a 10 ml dose of apple juice as a placebo. The main outcome focused on the impact of hydroxyzine on pre-operative hemodynamic alterations (heart rate, blood pressure, oxygen saturation, and breathing rate) before the administration of anesthetic agents. RESULTS: There is no statistically significant difference between hydroxyzine and placebo as regard pre-operative measured hemodynamics CONCLUSIONS: Oral hydroxyzine by a dose 1mg/kg does not affect pre-operative hemodynamics in pediatric patients undergoing adenotonsillectomy.