The Impact Of Quorum Sensing Quenching On Prevention Of Periodontal Disease

Abstract

Periodontal diseases are primarily caused by bacteria forming biofilms characterized by host response symptoms. Quorum sensing (QS), a regulatory mechanism, is essential for bacteria to communicate and produce virulence factors for disease colonization. Host-modulation of QS, particularly quorum quenching (QQ), has been suggested as a new strategy for preventing infectious diseases. Inhibiting virulence factor production without affecting bacterial colonization could regress periodontal disease to a healthy state by manipulating the composition of the biofilm. This review evaluates the potential of quorum sensing inhibition as an effective method to control periodontal disease, suggesting that it may be key to preventing irreversible periodontal damage.