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The Global Hidradenitis Suppurativa Atlas Methodology: Combining Global Proportions in a Pooled Analysis

202437 citationsOpen accessUniversity of Abuja

In plain language

This research outlines the methodology for the Global Hidradenitis Suppurativa Atlas (GHiSA) Global Prevalence studies, which are currently underway in 58 countries across six continents. The primary objective is to generate a single, combined summary of global proportions through a proportional meta-analysis. This process involves applying a logit transformation and synthesising the data using a random-effects model. A key aspect of this work is the novel standardisation of the prevalence studies, which allows for direct international comparisons of Hidradenitis Suppurativa prevalence. This standardised approach addresses and overcomes the significant heterogeneity observed in previous HS prevalence studies, making such comparisons possible for the first time.

Key takeaways

  • The GHiSA project is conducting Hidradenitis Suppurativa prevalence studies in 58 countries across six continents.
  • The methodology aims to create a single global summary of prevalence using a proportional meta-analysis.
  • The analysis involves a logit transformation and synthesis through a random-effects model.
  • Novel standardisation enables direct international comparisons of HS prevalence.
  • This approach addresses previous challenges caused by heterogeneity in past HS prevalence research.

Why it matters

This standardised methodology is crucial for accurately understanding the global burden of Hidradenitis Suppurativa. By enabling direct international comparisons, it provides a clearer picture of how common the condition is worldwide, which can inform public health strategies and resource allocation.

Commercialisation angle

The abstract describes a research methodology for conducting prevalence studies. It does not indicate any direct application pathway, specific user, or readiness level for commercialisation.

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Abstract

The GHiSA Global Prevalence studies are currently running simultaneously in 58 countries across six continents (Africa, Europe, Australia, North America, South America, and Asia). The goal of the combined global proportion is the generation of a single summary (i.e., proportional meta-analysis), which will be done after a logit transformation and synthesized using a random-effects model. The novel standardization of the Global Prevalence Studies conducted through GHiSA enables direct international comparisons, which were previously not possible due to substantial heterogeneity in past HS prevalence studies.

Research topics

  • Hidradenitis Suppurativa and Treatments
  • Colorectal and Anal Carcinomas

Sustainable Development Goals

Read the original research

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DOI: 10.1159/000536389

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