THE EFFECT OF MICRONUTRIENT SUPPLEMENTS ON ICSI OUTCOME IN POLYCYSTIC OVARIAN SYNDROME PATIENTS.

Abstract

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, affecting 8–13%, and is a major cause of infertility due to ovulatory dysfunction. It is diagnosed based on the presence of at least two features: hyperandrogenism, ovulatory dysfunction, or polycystic ovarian morphology. Insulin resistance, present in 35–80% of cases, and obesity, especially abdominal obesity, further worsen reproductive outcomes. Although women with PCOS often produce more oocytes during IVF, these are frequently of poor quality, leading to lower fertilization and implantation rates. Micronutrient supplementation has been shown to improve insulin sensitivity, hormonal profiles, and oxidative stress in PCOS patients. Nutrients such as selenium, chromium, folate, zinc, calcium, vitamin D, L-carnitine, and omega-3 fatty acids may enhance oocyte quality and fertility outcomes. This study aimed to assess the effect of micronutrient supplementation on intracytoplasmic sperm injection (ICSI) outcomes in infertile women with PCOS, exploring its potential as an adjuvant therapy.AIM:The aim of the study was to investigate the effect of micronutrient supplements on intracytoplasmic sperm injection outcomes in polycystic ovarian syndrome patients.