The Effect of Liver Transplantation Surgery on Anaerobic Gut Microbiota Community and Vitamin B12 levels

Abstract

The Anaerobic Gut Microbiota (AGM) is completely associated with human physiology. Compounds like Vitamins, Short Chain Fatty Acids (SCFAs), bile acids, choline metabolites, indole derivatives, polyamines, lipids, neurotransmitters, and neuroactive compounds were linked by the AGM. This study involved 28 Liver transplant (LT) patients from Gastrointestinal Surgery Center (GEC), Faculty of medicine Mansoura University. One hundred and twelve stool and blood samples were taken from all LT patients in the first week before and after the surgery. The results showed that the percentage of anaerobic bacteria isolated from patients before and after one week liver transplantation was (67.18% and 32.82%), respectively. On the other hand, the levels of vitamin B12 (VB-12) in the blood decreased simultaneously with the change of AGM in the first week after surgery compared to the first week before surgery, and this affected the levels of VB12 in the blood of patients with p-value of 0.001.