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article · Pharmaceutics

The Effect of Liraglutide on the Hypolipidemic, Anti-Inflammatory, and Antioxidant Properties of Atorvastatin Mediated via the Nrf2/HO-1 Signaling Pathway: In Vivo and In Silico Validation

2026Open accessAin Shams University

Abstract

: Our findings support targeting the Nrf2/HO-1 signaling pathway as a potential therapy for reversing hyperlipidemia and preventing mediators of inflammation and oxidative stress damage in the liver tissue. The evidence of increased efficacy observed with the combined atorvastatin and liraglutide supports a potential novel understanding of the complementary effects of atorvastatin and liraglutide. This finding requires further investigation to elucidate the combination's therapeutic advantages in treating metabolic disorder scenarios.

Research topics

  • Genomics, phytochemicals, and oxidative stress
  • Adipose Tissue and Metabolism
  • Peroxisome Proliferator-Activated Receptors

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DOI: 10.3390/pharmaceutics18040490

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