The Drug Paracetamol and Sodium Carboxymethyl Cellulose Interactions and Their Importances for Pharmaceutical and Biomedical Applications

Abstract

The interactions of naturally occurring polymers and medicaments, sodium carboxymethyl cellulose (Na-CMC) and Paracetamol (PCM), have attracted the interest of researchers in a variety of biomedical and pharmaceutical applications areas, such as drug delivery, cosmetics and tissue engineering. In our research described here, the effects of temperature and concentration of Na-CMC/PCM/water (W) mixed solutions were studied at various temperatures ranging from 20 °C to 45 °C. We highlighted that different regions can be distinguished in the aqueous Na-CMC/PCM/W complexes, depending on the composition and electrostatic interactions of the solutions, which are associated with significantly different phase behaviors.