article · Phytomedicine

The cytotoxic activities of the major diterpene extracted from Salvia multicaulis (Bardakosh) are mediated by the regulation of heat-shock response and fatty acid metabolism pathways in human leukemia cells

Heba K. Nabih
Mona Dawood
Mohamed‐Elamir F. Hegazy
Mohamed Elbadawi
Ahmed Abdelsadik
Rümeysa Yücer
Nasim Shahhamzehei
Taha A. Hussien
Nuha Mahmoud
Mahmoud A. A. Ibrahim
Sabine M. Klauck
Mohamed A. M. Atia
Thomas Efferth

20242 citationsOpen accessMinia University

Abstract

Candesalvone B methyl ester isolated from S. multicaulis exerted cytotoxicity by affecting apoptosis, cell division, and modulation of expression levels of genes contributing to the heat stress signaling and fatty acid metabolism pathways that could relieve drug resistance of leukemia cells.

Research topics

Metabolomics and Mass Spectrometry Studies
Traditional Chinese Medicine Analysis
Cholesterol and Lipid Metabolism

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DOI: 10.1016/j.phymed.2024.156023

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