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review · European journal of medical research

The association between H. pylori infection and cognitive deterioration: a systematic review and meta-analysis

2025Open accessAlexandria University

Abstract

This meta-analysis indicates a bidirectional association between H. pylori and cognitive decline. While H. pylori infection increased the overall risk of cognitive decline, no significant link was found with Alzheimer's disease. Conversely, Alzheimer's disease patients had a higher prevalence of H. pylori infection. High heterogeneity underscores the need for further well-designed studies to clarify this relationship.

Research topics

  • Helicobacter pylori-related gastroenterology studies
  • Gastroesophageal reflux and treatments
  • Whipple's Disease and Interleukins

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DOI: 10.1186/s40001-025-03160-8

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