article · Journal of Microencapsulation

The assessment of pharmacokinetics and neuroprotective effect of berberine hydrochloride-embedded albumin nanoparticles via various administration routes: comparative <i>in-vivo</i> studies in rats

Hany G. Attia
Maha E. Elmataeeshy
Mohamed Aleraky
Samar R. Saleh
Doaa A. Ghareeb
Hanan M. El-Nahas
Maha El Demellawy
Tarek Ibrahim

20248 citationsPharos University in Alexandria

Abstract

values at 0.75 h (444 ± 77.79 and 259 ± 42.41 ng/mL, respectively). BBR and its metabolite distribution in the liver and kidney were higher than in plasma. Intranasal and sublingual treatment improves antioxidants, proinflammatory, amyloidogenic biomarkers, and brain architecture, protecting the brain. In conclusion, neuroinflammation and neurodegeneration may be prevented by intranasal and sublingual BBR-BSA nanoparticles.

Research topics

Berberine and alkaloids research
Drug Solubulity and Delivery Systems
Advanced Drug Delivery Systems

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DOI: 10.1080/02652048.2024.2395976

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