article · Biomarker Research
The asialoglycoprotein receptor 1 (ASGR1) has an established role as a hepatic receptor that clears desialylated glycoproteins from the bloodstream. Recently, its role in health and disease has expanded beyond this from cardiovascular to cancer and viral infection. Circulating ASGR1 is associated with elevated risk of coronary artery disease. Preclinical studies have reinforced this, showing ASGR1 inhibition reduces atherosclerotic cardiovascular disease. ASGR1 controls platelet lifespan and function, thereby regulating coagulation and thrombosis. It also facilitates entry of bacteria and viruses into host cells, causing immunomodulatory effects, and plays dual roles in cancer - promoting and suppressing tumorigenesis. This review provides an in-depth overview of the latest mechanistic insights underlying the roles of ASGR1 in health and disease and elaborates on the progress of ASGR1-targeted therapies.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1186/s40364-026-00954-8
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
