article · Frontiers in Bioengineering and Biotechnology

The antimicrobial peptide EM86 loaded to gamma-irradiated sodium alginate/polyvinyl alcohol electrospun nanofibrous dressing treated multidrug-resistant Pseudomonas aeruginosa wound infections in BALB/c mice

S. A. M. METWALLY
Rehab Nabil Shamma
Amal E. Ali
Hassan Ahmed Abd El-Rehim
Hala Abd Allah Farrag
Omneya M. Helmy

2026Open accessCairo University

Abstract

Using computer-aided approaches, we designed EM86 with a bactericidal activity against MDR Gram-negative microorganisms and reduced toxicity to HSF compared to colistin. EM86-functionalized SA/PVA nanofibrous dressings offer a better treatment alternative for colistin-resistant infections in open wounds.

Research topics

Antimicrobial Peptides and Activities
Wound Healing and Treatments
Bacterial biofilms and quorum sensing

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DOI: 10.3389/fbioe.2026.1776154

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