Systematic review and meta-analyses of the role of drinking water sources in the environmental dissemination of antibiotic-resistant <i>Escherichia coli</i> in Africa

Abstract

<i>Escherichia coli</i> are pathogenic and antibiotic-resistant organisms that can spread to humans through water. However, there is sparse synthesised information on the dissemination of antibiotic-resistant <i>E. coli</i> through drinking water in Africa. This review provides an overview of the environmental spread of antimicrobial-resistant <i>E. coli</i> through drinking water in Africa. We performed a systematic review based on PRISMA guidelines, and 40 eligible studies from 12 countries were identified until June 2023. Four electronic databases (PubMed, Elsevier, AJOL, and DOAJ) were searched. Studies that employed phenotypic tests (<i>n</i> = 24/40) in identifying the bacterium outstripped those that utilised genome-based methods (<i>n</i> = 13). Of the 40 studies, nine and five, respectively, assessed the bacterium for antimicrobial resistance (AMR) phenotype and genotype. Multiple antibiotic resistance indices of 0.04-0.1 revealed a low level of antibiotic resistance. The detection of multidrug-resistant <i>E. coli</i> carrying resistance genes in certain water sources suggests that AMR-surveillance expansion should include drinking water.