Synthetic approaches and biological evaluation of nitrogen bridgehead thiazolo[3,2-a]pyrimidines

Abstract

Thiazolopyrimidines are bicyclic compounds formed by the fusion of thiazole and pyrimidine rings in a single molecular frame. The fusion of these two heterocyclic systems containing bridgehead nitrogen atom is attracting the attention of many medicinal chemists throughout the worldwide to explore the framework for its potential. This review article is an attempt to cover the literature survey of thiazolopyrimidine ring structures with bridging-head nitrogen covers thiazolo[3,2- a ]pyrimidines, preparation of the ring system via thioxopyrimidines, thiazoles and other miscellaneous approaches. In addition, some properties related to a broad bioactivity and pharmacology have been reported.