article · RSC Advances

Synthesis, cytotoxic activity, molecular docking, molecular dynamics simulations, and ADMET studies of novel spiropyrazoline oxindoles based on domino Knoevenagel–Michael cyclization as potent non-toxic anticancer agents targeting β-tubulin and EGFR, with anti-MRSA activity

Israa A. Seliem

20257 citationsOpen accessZagazig University

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Abstract

The search for novel, potent anticancer and antimicrobial agents remains a rapidly advancing and continuously evolving area within medicinal chemistry.

Research topics

Synthesis and biological activity
Synthesis and Biological Evaluation
Multicomponent Synthesis of Heterocycles

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DOI: 10.1039/d5ra01257k

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