Synthesis and docking of new Schiff-bases bearing urea as promising dual α-amylase and α-glucosidase inhibitors

Abstract

AIMS: ) for their in vitro antidiabetic activity against α-glucosidase and α-amylase. MATERIALS AND METHODS: values of all compounds against α-amylase and α-glucosidase. RESULTS: interacts with key residues TRP59 and GLN63 of α-amylase, supporting the experimental findings. CONCLUSIONS: enhance their antidiabetic activity, suggesting their potential as effective inhibitors of carbohydrate-metabolizing enzymes. Further studies are warranted to explore the therapeutic applications of these derivatives.