article · Applied Organometallic Chemistry
Nanocomposite films were fabricated using chitosan and gadolinium oxide nanoparticles at concentrations of 5 and 10 weight per cent via a coprecipitation and solution casting method. Structural testing through Fourier transform infrared spectroscopy, X-ray diffraction, and electron microscopy confirmed the integration of the nanoparticles, which had an estimated size of 36 nanometres. Incorporating gadolinium oxide increased the crystallinity of the chitosan matrix. When tested against one Gram-positive and two Gram-negative bacterial strains, the composite films demonstrated superior antibacterial efficacy compared to chitosan on its own. The nanocomposites also exhibited notable antioxidant activity in comparison with standard vitamin C. Furthermore, tests on MCF-7 breast cancer, HCT-116 colon cancer, and HepG-2 liver cancer cell lines showed clear anticancer effects, highlighting the material's potential in biomedical settings such as breast cancer treatment.
Finding materials that simultaneously combat bacterial infections, limit oxidative stress, and target cancer cells is a major objective in biomedical science. By showing that adding gadolinium oxide nanoparticles to chitosan enhances its structural, antibacterial, antioxidant, and anticancer properties, this work indicates that multifunctional composite films could assist in developing new therapeutic materials, particularly for addressing cancer and bacterial pathogens.
The work points towards biomedical applications, specifically in anticancer therapies and antibacterial surfaces or treatments. Potential users include biomedical product developers and pharmaceutical researchers working on cancer therapies or anti-infective formulations. However, this is early-stage laboratory research based on in vitro cell line and bacterial culture tests, meaning considerable further development and safety testing will be required before any clinical or commercial deployment.
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Driven by the continuous search for materials with antibacterial and anticancer applications, this study focuses on the fabrication of nanocomposite films using chitosan as the basis material, with the addition of gadolinium oxide nanoparticles at varying weight percentages (5 and 10 wt.% Gd 2 O 3 /CS). The films were made using the coprecipitation‐solution cast approach. The structural characteristics of the Gd 2 O 3 /CS films that were formed were investigated and confirmed using a range of analytical techniques, including Fourier transform infrared, X‐ray diffraction, and scanning electron microscopy–energy‐dispersive X‐ray spectroscopy. The X‐ray diffraction study provided unambiguous evidence of an increased degree of crystallinity in chitosan with the inclusion of gadolinia. The particle size was determined using the Debye–Scherrer formula, resulting in an estimated value of 36 nm. Following this, a thorough examination was undertaken to evaluate the antibacterial effectiveness against one strain of Gram‐positive bacteria and two strains of Gram‐negative bacteria. Our research has revealed that the efficacy of the inspected Gd 2 O 3 /CS as bactericides is superior to that of CS alone. Furthermore, the MCF‐7, HCT‐116, and HepG‐2 cell lines exhibited anticancer activity when exposed to the Gd 2 O 3 /CS nanocomposites. In addition, nanocomposites exhibit significant antioxidant activity in comparison with the conventional vitamin C. These findings provide evidence for the viability of our nanocomposites in combating breast cancer.
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DOI: 10.1002/aoc.7531
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