Submandibular gland carcinoma ex pleomorphic adenoma clinically mimicking a benign lesion

Abstract

Carcinoma expleomorphic adenoma (CXPA) is a malignant carcinoma arising from a primary or recurrent benign pleomorphic adenoma. The lesion is recognized to be an aggressive malignancy with high recurrence rates and a high metastatic rate. CXPA is commonly seen in the sixth or seventh decade of life and shows a predilection for females. It accounts for approximately 3–5% of all salivary neoplasms and 12% of all salivary gland malignancies. Histologically, CXPA is characterized by the presence of both epithelial and mesenchymal components. We present an unusual case of a submandibular gland CXPA that clinically mimicked a benign tumour. The case offers an interesting perspective on the management challenges and associated prognostic significance after a follow-up evaluation of 6 years.