STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE

Abstract

Globally trichinellosis (Trichinella species) is a risky parasitic zoonosis Anthelminthic such asoral albendazole® and mebendazole® commonly used to treatment are poorly water soluble withunfavo- rable bioavailability. This study evaluated the therapeutic efficacy of lactoferrin loadedon silver nanoparticles on Trichinella spiralis infection in experimental infected mice by parasitologicaland histopathological parameters. Mice were classified into 8 groups each of 5 mice.G1: Non infected non treated (normal), G2: Infected non treated (infected control), G3: In-fectedand albendazole, treated, G4: Infected and lactoferrin treated, G5: Infected and silver nanoparticlestreated, G6: Infected and lactoferrin loaded on silver nanoparticles treated, G7: Infectedand albendazole & lactoferrin, & G8: Infected and albendazole combined with lactoferrinloaded on silver nanoparticles treated.The results showed a significant decrease in all treated groups, markedly in T. spiralis larvalmuscles treated with combination of albendazole and lactoferrin loaded on silver nanoparticles(92.39%), with muscles histopathological changes