Study of the Significance of Long Noncoding RNAs: Taurine-upregulated Gene-1, Urothelial Carcinoma-associated-1, Nuclear Paraspeckle Assembly Transcript-1, and Metastasis-associated Lung Adenocarcinoma Transcript-1 in Multiple Myeloma

Abstract

Abstract BACKGROUND: Disease of multiple myeloma (MM) is a resistant blood cancer involving clonal plasma cells and marked by symptoms such as anemia, bone pain, and kidney failure. Long nonprotein-coding RNAs (lncRNAs), for instance, taurine-upregulated gene-1 (TUG1), nuclear paraspeckle assembly transcript-1 (NEAT1), urothelial carcinoma-associated-1 (UCA1), as well as metastasis-associated lung adenocarcinoma transcript-1 (MALAT1), show diagnostic and prognostic significance in MM, potentially serving as biomarkers. Our study aimed to identify the clinical utility of these lncRNAs in serum for disease management. MATERIALS AND METHODS: Forty MM patients and 40 control subjects were recruited. The levels of expression of 4 lnRNAs: TUG1, UCA1, NEAT1, and MALAT1 were measured using quantitative real-time polymerase chain reaction and then correlated to various disease parameters to predict their prognostic significance. RESULTS: TUG1, NEAT1, and MALAT1 expression levels were much elevated in myeloma patients in comparison with the control group, in contrast to UCA1 which showed lower expression levels in MM with negative correlation with the disease characteristics. Univariate and multivariate analyses showed that the four lnRNAs: UCA1, NEAT1, MALAT1, and TUG1 expressions were all independent factors linked to MM ( P < 0.001). CONCLUSION: These lnRNAs might be used as potential markers for myeloma prognosis.