Specific scores of glycated hemoglobin in the current diagnosis of cardiometabolic risk dysglycemia in Brazzaville, Republic of Congo

Abstract

Background and aim: The increase in the incidence of diabetes mellitus is one of the constellations of cardiometabolic risk in the world. As the specific diagnostic thresholds for dysglycemia are absent among African Bantou de Brazzaville, Republic of Congo justified this study. The aim of the study was to determine the performance of glycated hemoglobin in the diagnosis of dysglycemia. Methods: The cross-sectional survey involved 500 apparently healthy adult participants. The glycated hemoglobin was modelled using a National Glycohemoglobin Standardization Propram certified method and correlated with the Diabetes Control and Complication Trial. Diagnostic performance was defined using analysis of the receptor's operating characteristics. Results: The study included 225 men and 275 women, the mean age was 47.4-13.7 years, the levels of hemoglobin glycated on an everan erate equal to 5.5-5.9% and 6.0% (Se100% and Sp-100%) (p = 0.001) were characterized by perfect diagnostic performance and prevalence respectively for intermediate/prediabetes-sweetened hyperglycemia (13.8%) and diabetes mellitus (24.4%) with an area under curve equal to one. There was a positive and significant bivariate correlation between older age, fasting blood glucose, and increasing hemoglobin glyched to right Y (glycated hemoglobin) – 2.683; -0.077 - Age (years) - 0.789 - Glycemia (mmol/L). Conclusion: The epidemic of cardiometabolic risk was estimated to be 2/3 of prehypertension/high blood pressure, 4/10 of overweight/obesity and 1/4 of diabetes mellitus in 2018 and significantly higher than reported in 2004. This study showed that the recommended thresholds for diagnosing dysglycemia are not the same for Bantu populations