article · Immunopharmacology and Immunotoxicology

Sirt1/Nrf2/TNFα; TLR4/Myd88/NF-κB signaling pathways are involved in mediating hepatoprotective effect of bupropion in rat model of myocardial infarction

Walaa Yehia Abdelzaher
Diana Haj Ali
Mina Ezzat Attya
Ayman Geddawy
Dania S. Waggas
Heba K. Alshaeri
Abdel Hamid Sayed AboBakr Ali
Yasmine Ibrahim

20242 citationsMinia University

Abstract

BUP protects against liver injury on top of MI in rat model <i>via</i> modulation of Sirtuin type 1 (Sirt1)/Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/tumor necrosis factor α (TNFα); Toll-like receptor 4 (TLR4)/Hepatic myeloid differentiation primary response 88(Myd88)/NF-κB signaling pathways.

Research topics

Drug-Induced Hepatotoxicity and Protection
Pharmacological Effects of Natural Compounds
Vitamin C and Antioxidants Research

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DOI: 10.1080/08923973.2024.2415461

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