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Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study

Abstract

We found kataegis-positivity to be associated with poor PCa presentation and prognosis, irrespective of patient ancestry. Kataegis-related genomic instability occurring early and late during African derived tumourigenesis, may partly explain the heightened tumour and clinical heterogeneity observed for patients of African ancestry.

Research topics

  • Cancer Genomics and Diagnostics
  • Prostate Cancer Treatment and Research
  • Epigenetics and DNA Methylation

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DOI: 10.21203/rs.3.rs-7624142/v1

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