Significance of Ubiquitin-Conjugating Enzyme (UBE2C) and P53 Expression in Molecular Subtypes of Breast Carcinoma; An Immunohistochemical Study

Abstract

Background: Breast cancer (BC) is the most common malignant tumor in females worldwide. It is categorized into four main molecular subtypes. Ubiquitin-conjugating enzyme (UBE2C) is essential for the ubiquitin–proteasome system which regulates checkpoints in the cell cycle. Dysregulation of ubiquitination has been associated with different types of cancer. P53 is important tumor suppressor gene. In some cancers mutant p53 proteins not only lose tumor suppressive functions, but also acquire oncogenic activity. Aim: This study aims at evaluation of UBE2C and P53 expression in molecular subtypes of breast cancer and assessment of their role in pathogenesis and tumor progression. Materials and methods: This controlled retrospective study included selected 50 cases of breast cancer mastectomy specimens. UBE2C and P53 immunostaining were performed for all cases. Results: UBE2C expression showed highly significant statistical association with tumor stage (P