SIGNIFICANCE OF ELECTRO-OSMOSIS FORCES AND NANOPARTICLES FOR BLOOD FLOW THROUGH AN INCLINED, POROUS-SATURATED ARTERY WITH A COMBINATION OF STENOSIS AND ANEURYSM

Abstract

The aim of this research is to examine the usage of computational biomedical simulations to study the combined impact of electro-osmosis forces and nanoparticles on blood flow through an inclined, tapered, porous-saturated artery with both stenosis and aneurysm regions, subjected to magnetic fields and under body acceleration. Different shapes of gold (Au) nanoparticles are used in the analysis. Gold nanoparticles are primarily chosen for drug delivery applications due to their stability, non-toxic nature, chemical inertness, high versatility, and strong biocompatibility. The Carreau fluid model is adopted to simulate the non-Newtonian behavior of blood. In addition, a modified model of Darcy's law is applied to the Carreau model. The phenomena related to the applied electric field are described using the Poisson-Boltzmann equation. As the walls are considered to have a low zeta potential, the Poisson-Boltzmann equation is linearized using the Debye-Hückel approximation, resulting in a closed-form solution for a function of electrical potential. An approximation of mild stenosis is taken into account to reduce the governing equation, which is transformed from an irregular boundary to a regular boundary using radial coordinate transformation. Consequently, a numerical solution is developed using the method of finite difference and the findings are used to explore the impact of various factors on flow patterns, which are illustrated in terms of velocity, temperature, wall shear stress, flow rate, and flow resistance. The transverse comportment of blood flow patterns is also produced using streamlines.