Severe aplastic anemia patients’ outcome with postAllogeneic Stem cell transplantation cyclophosphamide

Abstract

Background Severe and very severe aplastic anemia (SAA, VSAA) is a critical condition that requires urgent intervention. Current guidelines suggest that Allogenic stem cell transplantation (Allo-SCT) from a matched sibling donor (MSD) ought to be regarded as primary therapy for those cases. The selection of conditioning regimen for transplantation may vary depending on the individual patient’s age, overall health, performance status, and any other underlying medical conditions they may have. Aim Evaluate the outcome of using Post Allo-SCT Cyclophosphamide in SAA patients receiving Fludarabine and Cyclophosphamide (FLU/CY) as a conditioning regimen. Study design Prospective study of 24 patients who had SAA and underwent MSD -Allo-SCT at a single center Using FLU/CY Post CY as a conditioning regimen. Results FLU/CY Post CY regimen was associated was a good survival rate (66.6%). Most common cause of mortality was septicemia secondary to chest infection. Also, we notice improvement in engraftment and transplant-related morbidity. Conclusion The FLU/CY Post CY regimen is a well-tolerated conditioning regimen that could be a suitable alternative for developing countries with limited healthcare resources, as it has the potential to improve overall survival and lower the hazard of evolving Graft Versus Host Disease (GVHD).