review · Pharmaceutics
Self-nano-emulsifying drug-delivery systems (SNEDDSs) are an emerging strategy to overcome the low oral bioavailability of many new drug molecules caused by insufficient water solubility. These systems consist of an oil phase, a surfactant, and a co-surfactant or co-solvent. SNEDDSs enhance drug solubilisation, improve stability within the gastrointestinal tract, and increase absorption, leading to better bioavailability. Their formulation can be optimised using phase diagrams or statistical design, and their characteristics are controlled through multiple orthogonal methods to ensure manufacturing quality, stability, and biological performance. Converting liquid SNEDDSs into solid dosage forms can further improve stability and patient compliance. This approach has been successful in oral drug delivery for both lipophilic and hydrophilic compounds, from experimental stages to marketed products.
Many new medications are poorly absorbed when taken orally due to their low water solubility. SNEDDSs provide a vital solution by improving how these drugs dissolve and are absorbed by the body. This technology can lead to more effective oral treatments and better patient outcomes for a wide range of pharmaceutical compounds.
This research describes Self-Nano-Emulsifying Drug-Delivery Systems (SNEDDSs), a technology already implemented in marketed products. It offers a solution for pharmaceutical companies to formulate poorly soluble drugs for oral administration, enhancing their efficacy and patient compliance. The approach is applicable to both lipophilic and hydrophilic compounds, indicating its broad utility in drug development and commercialisation, and is therefore near-market.
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Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs are composed of an oil phase, surfactant, and cosurfactant or cosolvent. SNEDDSs characteristics, their ability to dissolve a drug, and in vivo considerations are determinant factors in the choice of SNEDDSs excipients. A SNEDDS formulation can be optimized through phase diagram approach or statistical design of experiments. The characterization of SNEDDSs includes multiple orthogonal methods required to fully control SNEDDS manufacture, stability, and biological fate. Encapsulating a drug in SNEDDSs can lead to increased solubilization, stability in the gastro-intestinal tract, and absorption, resulting in enhanced bio-availability. The transformation of liquid SNEDDSs into solid dosage forms has been shown to increase the stability and patient compliance. Supersaturated, mucus-permeating, and targeted SNEDDSs can be developed to increase efficacy and patient compliance. Self-emulsification approach has been successful in oral drug delivery. The present review gives an insight of SNEDDSs for the oral administration of both lipophilic and hydrophilic compounds from the experimental bench to marketed products.
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DOI: 10.3390/pharmaceutics12121194
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