Seasonal malaria chemoprevention and mutations in Pfdhfr and Pfdhps genes in children in the health district of Nanoro, Burkina Faso

Abstract

Introduction: alleles before and after the 2021 annual campaign of SMC in the health district of Nanoro in Burkina Faso. Materials and Methods: gene using a nested PCR with restriction fragment length polymorphism approach. Results: quadruple mutant was higher in the study area but with no significant variation before and after SMC campaign (p>0.05). . Conclusions: mutant alleles were higher either in pre or post SMC. However, no significant variation in the prevalence of these alleles was observed following the SMC campaign suggesting that these high mutation frequencies may be the result of continuous use of SMC in Burkina Faso since 2014.