SCHIFF BASE FROM L-Glycine and 4-Hydroxybenzaldehyde AND ITS COMPLEXES WITH Co(II) and Cu(II): SYNTHESIS AND ANTIMICROBIAL ACTIVITY

Abstract

This study reports the synthesis and characterization of Schiff base ligands derived from 4-hydroxybenzaldehyde and L-glycine. The Schiff base was synthesized using a base catalyst (Potassium hydroxide). The derived Schiff base was reacted with metal salts (Cobalt (II) chloride pentahydrate and Copper (II) sulphate pentahydrate) to form Schiff base-metal complexes. The synthesized Schiff base, (E)-2-(4-hydroxybenzylideneamino) acetic acid and its metal complexes were characterized using Fourier Transform-Infrared (FT-IR) spectroscopy and solubility in selected solvents. The antimicrobial activity of the synthesized complexes was evaluated against strains of Staphylococcus aureus, Escherichia coli using standard agar diffusion method. The result demonstrated that the metal complexes exhibited enhanced antimicrobial activity compared to the Schiff base. The result shows the potential of the complexes as antimicrobial agents, highlighting the importance of metal-amino acid interactions in enhancing biological activity.