Rutin: Chemical properties, Pharmacokinetic properties, Biological activities

Abstract

Recently, due to their excellent safety history and potent therapeutic effects, medicinal plants have gained the interest of researchers. Herbal remedies have been utilized for centuries to both prevent and treat a variety of diseases. Flavonoids, among them, contain polyphenols, which are well known for having a wide range of beneficial medical effects. Rutin is Considered as one of the most important flavonoids and valuable phytochemicals in the pharmaceutical industry. The current study's objective was to evaluate rutin's advantages and disadvantages, utilizing the previously published researches. The pharmacokinetic properties and medical uses of this compound were investigated in details, with an emphasis on new findings, considering its potential relevance to numerous health benefits as antioxidant, hepatoprotective, nephroprotective, neuroprotective, anti-inflammatory, antimicrobial, antidiabetic, antitumor properties and testicular protective action. However, due to some drawbacks, like low absorption and poor solubility, its medicinal use is restricted. Furthermore, strategies to improve the pharmacokinetic profile of rutin are also suggested in light of its possible therapeutic use in the near future.